Let’s get started.<\/p>\n\n\n\n The main difference between in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) is the method used to fertilize the egg<\/a>.<\/p>\n\n\n\n With IVF (aka conventional insemination), numerous sperm are placed in a dish together with the eggs and allowed to fertilize naturally.<\/p>\n\n\n\n In ICSI, a single sperm is injected into each egg using a tiny needle.<\/p>\n\n\n\n IVF simulates what happens during natural fertilization<\/a>. Hundreds of sperm are allowed to interact with the egg, but only one enters.<\/p>\n\n\n\n ICSI is the better option in cases of male factor infertility. It may improve fertilization rates when there are low numbers of sperm or poor sperm quality on semen analysis.<\/p>\n\n\n\n ICSI may also be the better option in cases where conventional insemination has led to failed or lower than expected fertilization rate in a previous IVF cycle.<\/p>\n\n\n\n Lastly, ICSI may also increase fertilization rates in couples with unexplained infertility. However, it is unclear if these patients have improved live birth rates.<\/p>\n\n\n\n With that said, ICSI does not guarantee that the egg will fertilize or that the embryo will be of good quality.<\/p>\n\n\n\n ICSI can improve the success rate of IVF, particularly in cases of male factor infertility or poor fertilization in a prior cycle.<\/p>\n\n\n\n Some fertility clinics routinely use ICSI in most patients as the likelihood of a complete failed fertilization is low with ICSI.<\/p>\n\n\n\n However, the routine use of ICSI in cases without male factor infertility or poor fertilization rates has not been shown to improve overall success rates (Study 1)<\/a>(Study 2<\/a>).<\/p>\n\n\n\n Approximately 50 to 70 percent of eggs<\/a> will fertilize with ICSI. Lower fertilization rates may be seen in older women, those with fewer eggs, or when the sperm is of very poor quality.<\/p>\n\n\n\n ICSI may increase the risk of some complications, such as birth defects and genetic abnormalities<\/a> on rare occasions.<\/p>\n\n\n\n One study<\/a> of over 308,000 births, of which 6,100 came from IVF or IVF\/ICSI, noted that couples who underwent ICSI had an increased risk of birth defects. The IVF group did not appear to have an increased risk.<\/p>\n\n\n\n However, it is unclear if the defects are due to the ICSI itself or to the underlying infertility issues in the men that necessitated ICSI in the first place.<\/p>\n\n\n\n The second disadvantage of ICSI is that the procedure may damage the egg. Oocyte degeneration can occur due to the ICSI technique or an inherent defect in oocyte quality.<\/p>\n\n\n\n Lastly, ICSI increases the cost of an already costly process.<\/p>\n\n\n\n Several studies<\/a> have found an association between IVF\/ICSI children with a modestly increased risk of genitourinary, cardiovascular, musculoskeletal, and gastrointestinal abnormalities.<\/p>\n\n\n\n It is important to note that the absolute risk of birth defects is still low, and most children born through ICSI cycles are healthy. The risk of congenital malformation for children conceived through IVF\/ICSI is about 7%, compared to 4% i<\/a>n the general population.<\/p>\n\n\n\n One of the most common abnormalities is hypospadias – when the opening of the penis (the urethra) is not at the tip of the penis and is typically on the underside of the penis.<\/p>\n\n\n\n Studies of children conceived through ICSI have found no significant difference in psychological, neurological, cognitive, and pubertal outcomes compared to children conceived spontaneously. (Study 1<\/a>) (Study 2<\/a>).<\/p>\n\n\n\n ICSI babies can have children of their own. In general, ICSI does not affect the fertility of the child. There are some exceptions, such as cases in which male offspring inherit a Y chromosome microdeletion from their father.<\/p>\n\n\n\n Preimplantation genetic testing (PGT) is a procedure used to screen for genetic abnormalities in the embryo before we transfer<\/a> it back to the uterus.<\/p>\n\n\n\n PGT-A, also called aneuploidy screening, screens for the most common chromosomal abnormalities. PGT-M is used to test for specific genetic mutations that may be present in either parent.<\/p>\n\n\n\n Many fertility doctors argue that ICSI can make the PGT-A more accurate. In IVF, millions of sperm surround each egg. In theory, sperm that attached to the egg but didn’t fertilize the egg may leave some residue, which can alter the results.<\/p>\n\n\n\n On the other hand, ICSI is required for PGT-M as the specific genetic mutation being tested for may be present in one sperm, not another. As such, excess genetic material from other sperm cells can certainly invalidate the results.<\/p>\n\n\n\n ICSI does not improve embryo quality. ICSI helps improve fertilization rates in cases of poor sperm quality or quantity. It does not improve the quality of the embryo.<\/p>\n\n\n\n ICSI does lead to a slight increase in the risk of monochorionic twins<\/a> for unknown reasons. The theory is that the artificial opening created by ICSI may cause the embryonic mass to split.<\/p>\n\n\n\n ICSI is more expensive than IVF because it is a more complex procedure. It requires additional laboratory expertise, experience, resources, and time.<\/p>\n\n\n\n On the other hand, conventional insemination is a more straightforward procedure in which the sperm and the eggs are incubated in a petri dish overnight.<\/p>\n\n\n\n ICSI appears to lead to a slightly higher incidence of female infants than IVF. However, IVF treatment generally leads to a higher male-to-female ratio after a day five blastocyst transfer. The reason is that embryos are selected for transfer based on morphological appearance and how quickly they divide. Male embryos may develop quicker than female embryos and thus, are more likely to be chosen.<\/p>\n\n\n\n There is some evidence associating ICSI with autism<\/a>; however, the increased risk appears to be due to the higher likelihood of adverse pregnancy and birth outcomes. Babies born through assisted reproductive technologies (ART) are more likely to <\/p>\n\n\n\n ICSI doesn’t require as many sperm as IVF. With ICSI, only one motile sperm is needed for each egg.<\/p>\n\n\n\n That is one of the main reasons why ICSI benefits men with a low sperm count or poor sperm quality.<\/p>\n\n\n\n In addition, the embryologist picks the best sperm they can identify for ICSI use.<\/p>\n\n\n\n Embryologists place the semen sample under a microscope to assess the number of sperm present in the sample, their shape, and their motility.<\/p>\n\n\n\n Sperm that have normal morphology and good forward motility are chosen for the ICSI process.<\/p>\n\n\n\n ICSI does not increase the risk of Down syndrome. Chromosomal aneuploidies like Down syndrome are more likely due to advanced maternal age.<\/p>\n\n\n\n Unfortunately, ICSI treatment does not guarantee success the first time. Many variables affect success rates, such as the age of the female, the number of eggs retrieved<\/a> after ovarian stimulation, the medical history, the quality of the eggs, and the infertility diagnosis in both parents.<\/p>\n\n\n\n Pros of ICSI:<\/strong><\/p>\n\n\n\n Cons of ICSI:<\/strong><\/p>\n\n\n\n The decision to do an ICSI cycle should be made on a case-by-case with your fertility specialist.<\/p>\n\n\n\n If you have poor sperm quality or quantity, or if you’ve had failed fertilization in the past, ICSI may benefit you. However, current evidence does not support the routine use of ICSI in non-male factor cases.<\/p>\n\n\n\n Related Articles:<\/strong><\/p>\n\n\n\n Make An Appointment With Dr. Robles To Discuss Your Fertility Options Today!<\/strong><\/strong><\/p>\n\n\n\n![\"icsi](\"https:\/\/alexroblesmd.com\/wp-content\/uploads\/2022\/08\/icsi-vs-ivf-cover-image.png\")
<\/figure>\n\n\n\n\n\nWhat Is The Difference Between IVF and IVF with ICSI?<\/h2>\n\n\n\n
Which Is Better?<\/h2>\n\n\n\n
![\"picture](\"https:\/\/alexroblesmd.com\/wp-content\/uploads\/2022\/08\/ivf-vs-icsi.png\")
<\/figure>\n\n\n\nIs IVF More Successful With ICSI?<\/h2>\n\n\n\n
What Percentage Of Eggs Fertilize With ICSI? (Success Rates)<\/h2>\n\n\n\n
What Are The Disadvantages Of ICSI?<\/h2>\n\n\n\n
What Birth Defects Do You See in ICSI VS IVF?<\/h2>\n\n\n\n
Are ICSI Babies Healthy Otherwise?<\/h2>\n\n\n\n
Can ICSI Babies Have Babies?<\/h2>\n\n\n\n
Do You Need to Do ICSI in Cases of Preimplantation Genetic Testing?<\/h2>\n\n\n\n
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Other Related Questions<\/h2>\n\n\n\n
Does ICSI Improve Embryo Quality?<\/h3>\n\n\n\n
Does ICSI Increase The Chance Of Twins?<\/h3>\n\n\n\n
Does ICSI Cost More Than IVF?<\/h3>\n\n\n\n
Does ICSI Affect Gender?<\/h3>\n\n\n\n
Does ICSI Cause Autism?<\/h3>\n\n\n\n
How Many Sperm Do You Need For ICSI?<\/h3>\n\n\n\n
How Do Embryologists Pick Sperm For ICSI?<\/h3>\n\n\n\n
![\"a](\"https:\/\/alexroblesmd.com\/wp-content\/uploads\/2021\/09\/semen-analysis-sperm-parameters-1.png\")
<\/figure>\n\n\n\nDoes ICSI Increase The Chance Of Down Syndrome?<\/h3>\n\n\n\n
Does ICSI Work The First Time?<\/h3>\n\n\n\n
Summary of The Pros And Cons Of ICSI<\/h2>\n\n\n\n
Final Words:<\/strong> Should You Do ICSI With IVF?<\/h2>\n\n\n\n
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![\"alex](\"https:\/\/alexroblesmd.com\/wp-content\/uploads\/2023\/03\/alex-robles-md.jpeg\")
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